Functional studies of NKX2-2 in Ewing sarcoma. Homo sapiens strain:A673 cell line

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尤文肉瘤转录调控

NKX2-2基因功能

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA238366 数据链接链接失效反馈

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资源简介：

Domain analysis of NKX2-2's role in the regulation of transcription in Ewing sarcoma.

NKX2-2在尤因肉瘤（Ewing sarcoma）转录调控中作用的结构域分析

创建时间：

2014-02-14

The FLI portion of EWS/FLI contributes a transcriptional regulatory function that is distinct from its DNA-binding function in Ewing sarcoma [RNA-seq III]. The FLI portion of EWS/FLI contributes a transcriptional regulatory function that is distinct from its DNA-binding function in Ewing sarcoma [RNA-seq III]

尤文肉瘤转录调控

RNA-seq分析

The purpose of this study was to determine transcriptional regulatory activity of EWS/FLI mutants in an alternative, non-Ewing sarcoma cell line. EWS/FLI cDNA constructs including various deletions of

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RNA-seq data of knowk-down of STAG2 or EWSR1-FLI1 in Ewing sarcoma cell lines (siCT, siEF1 & siSA2)

尤文肉瘤转录调控

STAG2基因

STAG2, a member of cohesin, is one of the most recurrently mutated genes in human cancer. Here, we investigated STAG2 function in the context of Ewing sarcoma, an aggressive bone tumor driven by EWS-F

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EWS-FLI1-regulated Core Transcriptional Regulatory Circuit promotes Ewing sarcoma progression

尤文肉瘤转录调控

超级增强子回路

We identify and validate an Ewing sarcoma-specific CRC, which is under control of EWS-FLI1. Formed by KLF15, TCF4 and NKX2-2, this CRC apparatus coordinates the gene expression programs in Ewing sarco

NIAID Data Ecosystem30

EWS/FLI mediated reprogramming of 3D chromatin promotes an altered transcriptional state in Ewing sarcoma (RNA-Seq)

尤文肉瘤转录调控

染色质重编程

Ewing sarcoma is a prototypical fusion transcription factor-associated pediatric cancer that expresses EWS/FLI or highly related fusions. EWS/FLI dysregulates transcription to induce and maintain sarc

NIAID Data Ecosystem40

The FLI portion of EWS/FLI contributes a transcriptional regulatory function that is distinct from its DNA-binding function in Ewing sarcoma

尤文肉瘤转录调控

FLI蛋白功能研究

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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