Twins TS15

This resource describes fundamental features of the immune system (frequency of leukocyte subpopulations, cell surface protein expression) in a large cohort of twins. An accompanying manuscript uses a complementary dataset (link to be provided) to describe the association between immunophenotypes and gene variants (based on single nucleotide polymorphisms (SNPs)).
Conclusion:
The study of immunophenotypes in the context of genome wide association studies can provide mechanistic information about genetic control of normal human immunity and disease.

本数据集针对大型双胞胎队列，阐释了免疫系统的基础特征，涵盖白细胞亚群频率与细胞表面蛋白表达水平。配套研究论文采用互补数据集（链接将另行提供），分析免疫表型与基因变异之间的关联，该关联的分析基于单核苷酸多态性（single nucleotide polymorphisms, SNPs）。
结论：
在全基因组关联研究框架下开展免疫表型研究，可为阐明正常人体免疫与疾病的遗传调控机制提供机制层面的信息。