Acute administration of Desformylflustrabromine relieves chemically induced pain in CD-1 mice

The aim of this study was to assess the effects of Desformylflustrabromine on chemically induced pain. For this purpose, the formalin induced pain test and the acetic acid induced writhing response test were carried out in CD-1 mice. Both tests represent chemical assays for nociception. Results show that Desformylflustrabromine is effective in producing an analgesic effect in both the tests used for assessing nociception. These results suggest that Desformylflustrabromine has the potential to become a clinically used drug for pain relief.

本研究旨在评估去甲溴海兔毒素（Desformylflustrabromine）对化学诱导性疼痛的影响。为此，本研究在CD-1小鼠中开展了福尔马林致痛试验（formalin induced pain test）与乙酸诱导扭体反应试验（acetic acid induced writhing response test）。两种试验均为用于检测伤害感受（nociception）的化学实验模型。结果表明，去甲溴海兔毒素在这两种伤害感受评估试验中均能发挥有效的镇痛作用。上述结果提示，去甲溴海兔毒素具备开发为临床镇痛药物的潜力。