Dioxygen-Coupled Oxidative Amination of Styrene

Dioxygen-coupled oxidative amination of olefins is an attractive, but challenging, catalytic transformation. The present work describes the first general method for intermolecular oxidative amination of aryl olefins with molecular oxygen as the stoichiometric oxidant. This palladium-catalyzed reactivity is compatible with several different nitrogen nucleophiles, including oxazolidinone, phthalimide, pyrrolidinone, and p-toluenesulfonamide. The presence of a catalytic quantity of a Brønsted base in the reaction increases the catalytic activity and switches the reaction regioselectivity.烯烃与氧气耦合的氧化胺化反应是一类兼具应用吸引力与研究挑战的催化转化过程。本研究首次报道了以分子氧为化学计量氧化剂的芳基烯烃分子间氧化胺化通用合成方法。该钯催化反应可兼容多种氮亲核试剂，包括恶唑烷酮、邻苯二甲酰亚胺、吡咯烷酮及对甲苯磺酰胺。向反应体系中加入催化量的布朗斯特碱（Brønsted base），可提升催化活性并改变反应的区域选择性。