Genomic Resources for Global and Local Ancestry Estimation in a Captive Baboon Colony
收藏资源简介:
VCF files mapped to Panubis1.0 with 881 olive (Papio anubis) and yellow (Papio cynocephalus) baboons from the Southwest National Primate Research Center. VCF files were generated in two separate pipelines, first using Beagle 4.1 and Beagle 5.4 and additionally SHAPEIT5/IMPUTE5 to test if a pedigree-aware software reduced the number of evident phase switch errors. VCFs here have been phased and imputed in their respective pipelines, filtered for imputation accuracy with markers with less than 0.7 confidence removed using BCFTools, and then phase switch corrected using Tractor. Genomic resources (AIMs and Fixed markers) are based off of Panubis1.0 coordinates. Local ancestry estimation completed by RFMix and then phase-switch-corrected using Tractor.
本数据集涵盖来自西南国家灵长类研究中心的881只橄榄狒狒(Papio anubis)与黄狒狒(Papio cynocephalus)的VCF(变异检测格式,Variant Call Format)文件,所有文件均已比对至Panubis1.0参考基因组。上述VCF文件通过两套独立分析流程生成:第一套使用Beagle 4.1与Beagle 5.4工具,第二套额外采用SHAPEIT5/IMPUTE5工具,旨在验证家系感知型软件能否减少显著的相位切换错误。本数据集内的VCF文件已在各自流程中完成相位分型与基因型填充,随后通过BCFTools过滤掉置信度低于0.7的遗传标记以保障填充准确性,最终使用Tractor工具完成相位切换校正。相关基因组资源(祖先信息标记(Ancestry Informative Markers,简称AIMs)与固定标记)均基于Panubis1.0的基因组坐标构建。局部祖先推断通过RFMix工具完成,随后再次使用Tractor工具进行相位切换校正。



