Mouse blood gene expression after administration of 137 Cesium

In the current study, we investigated the gene expression response of blood cells of mice that were injected with variable amounts of 137Cs. We isolated total RNA from peripheral blood from mice with 0 (control), 158, 191, 215 and 259 uCi cesium source amount on days 2, 3, 5, 7 and 14 days after injection. Using Agilent Mouse Whole Genome microarrays, we identified x genes that were significantly differentially expressed across the 14-day time course of this study. We identified common biological functions affected that persisted across the 14-day study.本研究针对注射不同剂量¹³⁷Cs的小鼠血细胞的基因表达响应展开探究。我们于注射后第2、3、5、7及14天，从剂量为0（对照组）、158、191、215与259微居里的铯源剂量组小鼠的外周血中分离总RNA。采用安捷伦小鼠全基因组基因芯片（Agilent Mouse Whole Genome Microarrays），我们鉴定出了本研究14天时间进程中显著差异表达的x个基因，并识别出在整个14天研究周期中持续受到影响的共同生物学功能。