Circular RNAs impinge on non-cell-autonomous mechanisms to regulate tumorigenesis. [RNA-seq]

We report transcriptomic changes in mouse soft-tissue sarcoma cells upon knock-down of the endogenous circRNA, circCsnk1g3. We find that circCsnk1g3 knockdown results in upregulation of signaling pathways related to both production of and response to type-I and type-II interferons Transcriptomic profiling of soft-tissue sarcoma cells—control or knocked down for circCsnk1g3.本研究报道了内源性环状RNA（circular RNA, circRNA）circCsnk1g3被敲低后，小鼠软组织肉瘤细胞内的转录组变化情况。研究发现，circCsnk1g3的基因敲低会导致与I型和II型干扰素的产生及应答相关的信号通路出现上调。本数据集涵盖经circCsnk1g3敲低处理与对照处理的软组织肉瘤细胞的转录组分析数据。