Exome sequencing of thymus transplantation based spontaneous murine T cell acute lymphoblastic leukemia (T-ALL) model

We adapted a spontaneously-arising, genetically-heterogeneous, thymic transplantation-based murine model of T-ALL, recapitulating key histopathological and genetic features of the human disease, to the preclinical testing of targeted and immune-directed therapies. Wild-type thymus-derived T-ALL samples were subjected to exome sequencing我们将一种自发形成、具有遗传异质性的、基于胸腺移植的T细胞急性淋巴细胞白血病（T-ALL）小鼠模型适配于靶向治疗与免疫导向疗法的临床前测试，该模型可重现人类该病的关键组织病理学与遗传学特征。随后，野生型胸腺来源的T-ALL样本接受了外显子组测序。