Data_Sheet_1_Health behavioral responses to parental myocardial infarction and impact on own risk of disease in the general population.pdf

AimsA family history of coronary heart disease increases one's own risk of experiencing cardiovascular disease and death. An implication of the hereditary nature of the disease is that individuals are provided information about their own risk when a parent is affected, potentially leading them to engage in behaviors that reduce their own risk. In this study, we assessed how a 10-year risk of a cardiovascular event, measured by SCORE, changes for the offspring in response to a parent experiencing a myocardial infarction.
MethodsWe analyzed 19,995 individuals from the general population in the Copenhagen City Heart Study of whom 2,071 had a parent, who suffered from a myocardial infarction during four decades of observation using fixed-effects regressions.
ResultsFollowing a parental myocardial infarction, individuals reduced their 10-year risk by 0.16 percentage points constituting a 7.1% reduction of baseline risk. Male participants had the largest change in the risk SCORE following an event of the mother, with a 12.4% reduction from the baseline risk. The degree of response contingent on their own level of risk was found to be the largest for individuals with a 10-year risk between 5% and 10%, who also showed a reduction in systolic blood pressure following paternal myocardial infarction. Parental myocardial infarction was associated with an increased smoking rate in individuals with a baseline risk above 10%, while reductions in risk were seen for individuals with a lower baseline risk.
ConclusionFollowing a parental event, individuals reduced their 10-year risk with the largest reductions in their own risk, as observed in men and individuals experiencing a maternal event. The response was the largest for individuals with a 10-year risk for myocardial infarction between 5 and 10%.

一、研究目的：冠心病家族史会提升个体自身罹患心血管疾病及死亡的风险。鉴于该疾病具有遗传特性，当父母一方罹患心肌梗死（myocardial infarction）时，个体可获知自身的患病风险，这可能促使其采取降低自身风险的相关行为。本研究旨在评估：当父母发生心肌梗死后，通过SCORE（系统性冠心病风险评估量表）测算的10年心血管事件发生风险，会对子代产生何种变化。
二、研究方法：本研究对哥本哈根城市心脏研究（Copenhagen City Heart Study）中的19995名普通人群受试者进行数据分析，其中2071名受试者的父母在长达40年的随访观察期间罹患过心肌梗死，本研究采用固定效应回归模型（fixed-effects regressions）开展统计分析。
三、研究结果：父母发生心肌梗死后，受试者的10年心血管事件风险降低0.16个百分点，较基线风险下降7.1%。其中，男性受试者在母亲发生心肌梗死后的SCORE风险评分变化最为显著，风险较基线降低12.4%。风险响应程度与个体自身基线风险水平相关：10年风险处于5%~10%区间的个体响应幅度最大，且在父亲发生心肌梗死后，其收缩压水平也出现显著下降。基线风险高于10%的个体，其吸烟率反而出现上升；而基线风险较低的个体则观察到风险水平下降。
四、研究结论：父母发生心肌梗死事件后，受试者的10年心血管事件风险有所降低，其中男性受试者以及母亲发生心肌梗死的个体风险下降幅度最大。风险响应幅度最大的群体为基线10年心肌梗死发病风险处于5%~10%区间的个体。