Data_Sheet_1_Identifying Changes of Brain Regional Homogeneity and Cingulo-Opercular Network Connectivity in First-Episode, Drug-Naïve Depressive Patients With Suicidal Ideation.docx

ObjectiveAdult patients with major depressive disorder (MDD) may not actively reveal their suicidal ideation (SI). Therefore, this study is committed to finding the alterations in the cingulo-opercular network (CON) that are closely related to SI with multi-imaging methods, thus providing neuroimaging basis for SI. MethodA total of 198 participants (129 MDD patients and 69 healthy controls) were recruited and evaluated with the Montgomery–Asberg Depression Rating Scale (MADRS). The healthy individuals formed the HC group, while the MDD patients were subdivided into no SI MDD (NSI, n = 32), mild SI MDD (MSI, n = 64), and severe SI MDD (SSI, n = 33) according to their MADRS item 10. We obtained MRI data of all participants and applied regional homogeneity (ReHo) analysis to verify a previous finding that links CON abnormality to SI. In addition, we employed the structural covariance network (SCN) analysis to investigate the correlation between abnormal structural connectivity of CON and SI severity. ResultsCompared to those of the HC group, MDD ReHo values and gray matter volume (GMV) were consistently found abnormal in CON. ReHo values and GMV of the right orbital inferior frontal gyrus (ORBinf.R) in the MDD group decreased with the increase of SI. Compared to the HC group, the MDD patients showed enhanced structural connectivity of three pairs of brain regions in CON [ACC.L–left superior frontal gyrus (SFG.L), SFG.L–left middle temporal gyrus (MTG.L), and the SFG.L–left post-central gyrus (PoCG.L)]. Compared with that of the NSI and MSI groups, the structural connectivity of three pairs of brain regions in CON is enhanced in the SSI groups [ORBinf.L–right ventral posterior cingulate gyrus (VPCC.R), VPCC.R–SFG.R, and SFG.R–PoCG.R]. ConclusionOur findings showed the distinctive ReHo, GMV, and SCN pattern of CON in MDD patients with SI; and with the severity of suicide, abnormal brain regions increased. Our finding suggested that MDD patients with different severity of SI have different neuroimaging changes.研究目的：重性抑郁障碍（major depressive disorder, MDD）成年患者往往不会主动表露其自杀意念（suicidal ideation, SI）。本研究旨在通过多模态影像学方法，探寻与自杀意念密切相关的扣带回-岛盖网络（cingulo-opercular network, CON）异常改变，从而为自杀意念的临床识别提供神经影像学依据。 研究方法：本研究共招募198名受试者，其中129名重性抑郁障碍患者与69名健康对照者，所有受试者均接受蒙哥马利-艾斯伯格抑郁评定量表（Montgomery–Asberg Depression Rating Scale, MADRS）评估。根据MADRS第10项得分，将健康个体划分为健康对照（HC）组；将重性抑郁障碍患者进一步分为无自杀意念组（no SI MDD, NSI, n=32）、轻度自杀意念组（mild SI MDD, MSI, n=64）与重度自杀意念组（severe SI MDD, SSI, n=33）。本研究采集所有受试者的磁共振成像（MRI）数据，采用局部一致性（regional homogeneity, ReHo）分析验证此前关于扣带回-岛盖网络异常与自杀意念相关的研究发现；此外，通过结构协变网络（structural covariance network, SCN）分析，探究扣带回-岛盖网络结构连接异常与自杀意念严重程度之间的关联。 研究结果：与健康对照组相比，重性抑郁障碍患者的扣带回-岛盖网络局部一致性值与灰质体积（gray matter volume, GMV）均存在显著异常。随着自杀意念严重程度的升高，重性抑郁障碍患者右侧眶额下回（right orbital inferior frontal gyrus, ORBinf.R）的局部一致性值与灰质体积均呈下降趋势。与健康对照组相比，重性抑郁障碍患者扣带回-岛盖网络内三对脑区的结构连接显著增强，分别为左侧前扣带回（ACC.L）-左侧额上回（SFG.L）、左侧额上回（SFG.L）-左侧颞中回（MTG.L）以及左侧额上回（SFG.L）-左侧中央后回（PoCG.L）。与无自杀意念组与轻度自杀意念组相比，重度自杀意念组患者扣带回-岛盖网络内三对脑区的结构连接进一步增强，分别为左侧眶额下回（ORBinf.L）-右侧腹后扣带回（VPCC.R）、右侧腹后扣带回（VPCC.R）-右侧额上回（SFG.R）以及右侧额上回（SFG.R）-右侧中央后回（PoCG.R）。 研究结论：本研究揭示了伴自杀意念的重性抑郁障碍患者扣带回-岛盖网络在局部一致性、灰质体积以及结构协变网络层面的特异性改变模式，且随着自杀意念严重程度的升高，异常脑区范围进一步扩大。上述结果表明，不同自杀意念严重程度的重性抑郁障碍患者存在差异化的神经影像学特征改变。