<i>m</i>-CPBA/KOH: An Efficient Reagent for Nucleophilic Epoxidation of <i>g</i><i>em</i>-Deactivated Olefins^†

The m-chloroperoxybenzoate anion (generated from m-CPBA and bases such as K2CO3 or KOH) is a highly efficient nucleophilic epoxidating reagent for strongly deactivated olefins containing two electron-withdrawing groups at the same carbon, under mild conditions which affect neither other double bonds nor electrophilic oxidizable centers such as sulfoxides.由间氯过氧苯甲酸（m-CPBA）与碳酸钾（K₂CO₃）或氢氧化钾（KOH）等碱反应生成的间氯过氧苯甲酸根阴离子（m-chloroperoxybenzoate anion），是一类高效亲核环氧化试剂。该试剂可在温和反应条件下，对同一碳原子上连有两个吸电子基团的强钝化烯烃实现环氧化，且此反应不会对其他双键或亚砜类亲电可氧化位点造成影响。