Crystal structure of the Mycobacterium tuberculosis transcriptional repressor EthR2 in complex with BDM41420

Crystal structure of the Mycobacterium tuberculosis transcriptional repressor EthR2 in complex with BDM41420 Descriptor: 4,4,4-trifluoro-1-(3-phenyl-1-oxa-2,8-diazaspiro[4.5]dec-2-en-8-yl)butan-1-one, Probable transcriptional regulatory protein Authors: Wohlkonig, A, Remaut, H, Tanina, A, Meyer, F, Willand, N, Baulard, A.R, Wintjens, R. Deposit date: 2016-02-23 Release date: 2017-04-26 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420. Science, 355, 2017

结核分枝杆菌转录阻遏蛋白EthR2与BDM41420复合物的晶体结构。配体描述：4,4,4-三氟-1-(3-苯基-1-氧杂-2,8-二氮杂螺[4.5]癸-2-烯-8-基)丁-1-酮，该蛋白为潜在转录调控蛋白。作者：Wohlkonig, A、Remaut, H、Tanina, A、Meyer, F、Willand, N、Baulard, A.R、Wintjens, R。保藏日期：2016-02-23；发布日期：2017-04-26；最后修改日期：2024-01-10。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.4埃（Å）。引用文献：《通过螺异恶唑啉类化合物SMARt-420逆转结核分枝杆菌的抗生素耐药性》，《科学》，第355卷，2017年。