tRNA-Guanine Transglycosylase (TGT) in Complex with 6-Amino-2-{[2-(piperidin-1-yl)ethyl]amino}-1H,7H,8H-imidazo[4,5-g]quinazolin-8-one

tRNA-Guanine Transglycosylase (TGT) in Complex with 6-Amino-2-{[2-(piperidin-1-yl)ethyl]amino}-1H,7H,8H-imidazo[4,5-g]quinazolin-8-one Descriptor: 6-amino-2-{[2-(piperidin-1-yl)ethyl]amino}-3,5-dihydro-8H-imidazo[4,5-g]quinazolin-8-one, CHLORIDE ION, DIMETHYL SULFOXIDE, ... Authors: Neeb, M, Heine, A, Klebe, G. Deposit date: 2014-04-15 Release date: 2014-07-09 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.35 Å) Cite: Beyond Affinity: Enthalpy-Entropy Factorization Unravels Complexity of a Flat Structure-Activity Relationship for Inhibition of a tRNA-Modifying Enzyme. J.Med.Chem., 57, 2014

与配体6-氨基-2-{[2-(1-哌啶基)乙基]氨基}-1H,7H,8H-咪唑并[4,5-g]喹唑啉-8-酮结合的tRNA-鸟嘌呤转糖苷酶（tRNA-Guanine Transglycosylase, TGT）。描述：本复合物包含6-氨基-2-{[2-(1-哌啶基)乙基]氨基}-3,5-二氢-8H-咪唑并[4,5-g]喹唑啉-8-酮、氯离子（CHLORIDE ION）、二甲基亚砜（DIMETHYL SULFOXIDE）等组分。作者：Neeb, M、Heine, A、Klebe, G。沉积日期：2014-04-15。发布日期：2014-07-09。最后修改日期：2023-09-20。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.35埃（Å）。引用文献：《超越亲和力：焓-熵分解揭示tRNA修饰酶抑制剂的扁平构效关系复杂性》，《药物化学杂志》（J.Med.Chem.），57卷，2014年。