Treatment with commonly used antiretroviral drugs induces a type I/III interferon signature in the gut in the absence of HIV infection: Proteomics from MTN017

The purpose of this data set was to measure how the expression of proteins in rectal biopsies is affected by use of oral tenofovir disoproxil fumarate/emtricitabine for prevention of HIV infection. Proteins were measured by mass spectrometry from samples taken from the MTN-017 study at baseline and after two months of daily oral tenofovir disoproxil fumarate/emtricitabine.
In the raw_data tab, each row is a sample. There are several columns describing each sample and then many columns containing the expression level for each detected protein. Expression levels were adjusted for batch effects using ComBat.
In the protein_lookup tab, there is one row per protein detected, mapping from UniProt ID to gene symbol and Entrez Gene ID.
The complete methods and results are described here: https://doi.org/10.1101/701961

本数据集旨在量化评估口服富马酸替诺福韦二吡呋酯/恩曲他滨（oral tenofovir disoproxil fumarate/emtricitabine）用于人类免疫缺陷病毒（HIV）感染预防时，对直肠活检组织中蛋白质表达的影响。研究人员采用质谱法，对MTN-017研究中基线期及每日口服该药物两个月后的采集样本内的蛋白质进行了定量检测。在raw_data标签页中，每一行对应一个样本，包含若干描述样本特征的列，以及多列展示各检测蛋白表达水平的数值列。蛋白表达水平已通过ComBat方法完成批次效应校正。在protein_lookup标签页中，每一行对应一个被检测到的蛋白，实现了UniProt ID与基因符号（gene symbol）、Entrez基因ID（Entrez Gene ID）的映射关联。完整的研究方法与结果可查阅以下链接：https://doi.org/10.1101/701961