Association between triglyceride-glucose index and acute kidney injury in patients with acute myocardial infarction based on Medical Information Mart for Intensive Care database : A cross-sectional study.

<strong>Methods: </strong>Participants were enrolled from Medical Information Mart for Intensive Care IV (MIMICIV) and grouping of subjects based on the quartile interval of the TyG index. With the presence of AKI as the main outcome, a logistic regression model was constructed. The correlation of the TyG index with the results obtained was examined by using a restricted cubic spline (RCS) model. <strong>Results:</strong> Among the 1,101 AMI participants, 64.7% were male patients and the overall incidence rate of AKI was 37.1%. The results of multivariate Logistic regression analysis (LRA) revealed independent correlation of the TyG index with increased AKI risk <strong>[odds ratio (OR) = 2.23; confidence interval (CI) = 1.59 to 3.17; P &lt; 0.001]</strong>. Q4 (9.5-12.208) in the TyG index quartile was independently correlated with increased AKI risk<strong> (OR = 2.99, 95% CI = 1.64 to 5.46, P &lt; 0.001)</strong>. The RCS model showed that the AKI risk increased linearly as the TyG index increased (P=0.313).

<strong>方法：</strong> 本研究从重症监护医学信息数据库IV（Medical Information Mart for Intensive Care IV, MIMIC-IV）中纳入研究对象，依据甘油三酯葡萄糖乘积指数（TyG index）的四分位数区间对研究对象进行分组。以急性肾损伤（AKI）为主要结局事件，构建logistic回归（logistic regression）模型；采用限制性立方样条（restricted cubic spline, RCS）模型分析TyG指数与研究结局的相关性。<strong>结果：</strong> 本研究共纳入1101例急性心肌梗死（AMI）患者，其中男性患者占比64.7%，整体急性肾损伤发生率为37.1%。多因素logistic回归分析（LRA）结果显示，TyG指数与急性肾损伤风险升高存在独立相关性[比值比（OR, odds ratio）=2.23；95%置信区间（CI, confidence interval）=1.59~3.17；P<0.001]。TyG指数四分位数分组中的Q4组（9.5~12.208）同样与急性肾损伤风险升高存在独立相关性（OR=2.99，95%CI=1.64~5.46，P<0.001）。限制性立方样条模型分析结果显示，随着TyG指数升高，急性肾损伤风险呈线性升高趋势（P=0.313）。