Agomelatine release from FDM 3D printed ethanol gel-coated pyramid microneedle systems

Raw data from release studies of agomelatine (AGM) from microneedle systemsMicroneedle system specifications:3D printing method: Fused Deposition Modeling (FDM)microneedle shape: Pyramidprinting material: polylactic acid (PLA)coating-gel type: ethanol gelDrug release studies: The permeation of agomelatine (AGM) was evaluated using Franz Diffusion Cells (Teledyne Hanson 376 Research, USA) without using any membrane.Quantification of AGM: The amount of AGM permeated was analyzed using High-Performance Liquid Chromatography (HPLC) (Shimadzu Nexera-I LC-2040C, Japan) with LabSolution Lite software.Chromatographic Conditions:Column: Reversed-phase C18 (HyperClone BDS C18, 5 µm, 4.6 × 250 mm, Phenomenex, Torrance, CA, USA)Column Temperature: 30.0 ± 0.2°CMobile Phase: Acetonitrile and 0.05 M potassium dihydrogen phosphate solution (pH = 2.9, adjusted with 85% orthophosphoric acid) in a 35:65 ratioMode: IsocraticFlow Rate: 1.0 mL/minDetection Wavelength: 230 nmThe set contains data in LCD/ LCB format, created using the LabSolutions software (HPLC, Nexera LC 2040C). Data file (.lcd) contains all analysis results and acquisition information from the following files. Data in .txt format can be read without the need for LabSolutions software.

本数据集包含微针系统中阿戈美拉汀（agomelatine，AGM）释放研究的原始数据。

微针系统规格：
3D打印方法：熔融沉积建模（Fused Deposition Modeling，FDM）
微针形状：金字塔形
打印材料：聚乳酸（polylactic acid，PLA）
包衣凝胶类型：乙醇凝胶

药物释放研究：采用无膜Franz扩散池（Franz Diffusion Cells，美国Teledyne Hanson 376 Research）评估阿戈美拉汀的透皮渗透情况。

阿戈美拉汀定量分析：采用高效液相色谱（High-Performance Liquid Chromatography，HPLC，日本岛津Nexera-I LC-2040C）结合LabSolution Lite软件，对透皮渗透的阿戈美拉汀含量进行分析。

色谱条件：
色谱柱：反相C18柱（HyperClone BDS C18，5 μm，4.6 × 250 mm，美国Phenomenex，加利福尼亚州托伦斯市）
柱温：30.0 ± 0.2℃
流动相：乙腈与0.05 M磷酸二氢钾溶液（用85%正磷酸调节pH至2.9）按35:65的体积比混合
洗脱模式：等度洗脱
流速：1.0 mL/min
检测波长：230 nm

本数据集包含由LabSolutions软件（适配HPLC Nexera LC 2040C）生成的LCD/LCB格式数据。.lcd格式的数据文件包含全部分析结果及采集文件信息；无需LabSolutions软件即可读取.txt格式的数据。