DATASET Skin-Based Vaccination: A Systematic Mapping Review of the Types of Vaccines and Methods Used and Immunity and Protection Elicited in Pigs

Dataset listing all publications used in systematic mapping review. This file contains the dataset, a dictionary and values worksheets for the following publication: Skin-Based Vaccination: A Systematic Mapping Review of the Types of Vaccines and Methods Used and Immunity and Protection Elicited in Pigs. Vaccines 2023 Inés Có-Rives 1, Ann Ying-An Chen 1, Anne C Moore 1 PMID: 36851328 PMCID: PMC9962282 DOI: 10.3390/vaccines11020450 The advantages of skin-based vaccination include induction of strong immunity, dose-sparing, and ease of administration. Several technologies for skin-based immunisation in humans are being developed to maximise these key advantages. This route is more conventionally used in veterinary medicine. Skin-based vaccination of pigs is of high relevance due to their anatomical, physiological, and immunological similarities to humans, as well as being a source of zoonotic diseases and their livestock value. We conducted a systematic mapping review, focusing on vaccine-induced immunity and safety after the skin immunisation of pigs. Veterinary vaccines, specifically anti-viral vaccines, predominated in the literature. The safe and potent skin administration to pigs of adjuvanted vaccines, particularly emulsions, are frequently documented. Multiple methods of skin immunisation exist; however, there is a lack of consistent terminology and accurate descriptions of the route and device. Antibody responses, compared to other immune correlates, are most frequently reported. There is a lack of research on the underlying mechanisms of action and breadth of responses. Nevertheless, encouraging results, both in safety and immunogenicity, were observed after skin vaccination that were often comparable to or superior the intramuscular route. Further research in this area will underlie the development of enhanced skin vaccine strategies for pigs, other animals and humans. <strong>Keywords: </strong>epicutaneous; epidermal; intradermal; needle-free; percutaneous; pig; skin; transcutaneous; transdermal; vaccine.本数据集收录了系统映射综述（systematic mapping review）中使用的全部文献。本文件包含以下研究的数据集、词典及数值工作表：《经皮疫苗接种：猪用疫苗类型、接种方法及诱导免疫与保护效果的系统映射综述》，发表于《Vaccines》2023年，作者为Inés Có-Rives、Ann Ying-An Chen、Anne C Moore，PMID：36851328，PMCID：PMC9962282，DOI：10.3390/vaccines11020450。 经皮疫苗接种具备诱导强效免疫、节约接种剂量以及给药便捷等核心优势。目前多款面向人类的经皮免疫技术正处于研发阶段，以最大化发挥上述优势。该接种途径在兽医学领域的应用更为普遍。由于猪在解剖学、生理学与免疫学层面与人类高度相似，且可作为人畜共患病的传染源，同时具备畜牧经济价值，因此针对猪的经皮疫苗接种具有极高研究价值。 本研究开展了一项系统映射综述，聚焦猪经皮免疫后疫苗诱导的免疫反应与接种安全性。现有相关文献中，兽用疫苗（尤其是抗病毒疫苗）占比最高。研究频繁证实，含佐剂的疫苗（尤以乳剂制剂为代表）可安全且高效地经皮接种于猪只。目前存在多种经皮免疫接种方法，但相关术语缺乏统一标准，且对接种途径与使用器械的描述亦不够精准。相较于其他免疫相关性指标，抗体应答的相关报道最为常见。目前针对免疫应答的潜在作用机制与应答广度的研究仍较为匮乏。尽管如此，经皮疫苗接种后仍展现出了令人鼓舞的安全性与免疫原性表现，其效果通常可媲美甚至优于肌内接种途径。该领域的后续研究将为猪只、其他动物乃至人类的优化经皮疫苗接种策略开发奠定理论基础。 关键词：表皮外接种（epicutaneous）、表皮（epidermal）、皮内（intradermal）、无针（needle-free）、经皮（percutaneous）、猪（pig）、皮肤（skin）、经皮（transcutaneous）、透皮（transdermal）、疫苗（vaccine）。