Differential gene expression data of commercial compounds used to assess the performance of human TeraTox assay

The dataset supplements the publication `Optimization of the TeraTox assay for preclinical teratogenicity assessment`. 

2022-02-18-TeraTox-commercial-logFC.gct: log2FC matrix of genes by compounds (in concentration ranges)

2022-02-18-TeraTox-commercial-pScore.gct: p-scores (log 10 transformed p-values with the sign of logFC) of genes by compounds

2022-02-18-TeraTox-commercial-featureData.txt: feature annotation in TSV format

2022-02-18-TeraTox-commercial-phenoData.txt: sample annotation in TSV format

2021-06-10-gcGeneFactorAnno-withPositiveCoefs.tsv: gene membership of germ-layer factors, with germ-layer annotation and average expression in copies per million (cpm).

Citation: Jaklin, Manuela, Jitao David Zhang, Nicole Schäfer, Nicole Clemann, Paul Barrow, Erich Küng, Lisa Sach-Peltason, Claudia McGinnis, Marcel Leist, and Stefan Kustermann. “Optimization of the TeraTox Assay for Preclinical Teratogenicity Assessment.” Toxicological Sciences 188, no. 1 (July 1, 2022): 17–33. https://doi.org/10.1093/toxsci/kfac046.

本数据集为学术论文《优化用于临床前致畸性评价的TeraTox检测方法》（Optimization of the TeraTox assay for preclinical teratogenicity assessment）的配套补充数据集。

2022-02-18-TeraTox-commercial-logFC.gct：针对不同浓度受试化合物的基因log2倍数变化（log2FC）矩阵
2022-02-18-TeraTox-commercial-pScore.gct：受试化合物对应的基因p分数（p-score）矩阵，该分数为经log10转换的p值，并附带logFC的符号信息
2022-02-18-TeraTox-commercial-featureData.txt：采用TSV格式存储的特征注释文件
2022-02-18-TeraTox-commercial-phenoData.txt：采用TSV格式存储的样本注释文件
2021-06-10-gcGeneFactorAnno-withPositiveCoefs.tsv：生殖层因子的基因归属信息，附带生殖层注释以及以每百万拷贝数（cpm）为单位的平均表达量。

引用文献：Jaklin, Manuela、Jitao David Zhang、Nicole Schäfer、Nicole Clemann、Paul Barrow、Erich Küng、Lisa Sach-Peltason、Claudia McGinnis、Marcel Leist、Stefan Kustermann. 《优化用于临床前致畸性评价的TeraTox检测方法》（Optimization of the TeraTox assay for preclinical teratogenicity assessment）. 发表于《毒理科学》（Toxicological Sciences）2022年7月1日第188卷第1期，第17-33页。DOI：10.1093/toxsci/kfac046.