Inhibiting bridge integrator 2 phosphorylation leads to improved oocyte quality, ovarian health and fertility in aging and after chemotherapy in mice

Bin2 mutated frequently in diverse human cancers including ovarian cancer. Interestingly, we primarily showed that expression of these conserved mutants in diverse normal cell lines could up-regulate mTOR activity. Thus, it might be a novel mTOR-involved gene essential for not only tumorigenesis but also fertility.

Bin2在包括卵巢癌在内的多种人类癌症中频繁发生突变。有趣的是，本研究主要证实，在多种正常细胞系中表达这些保守突变体，可上调哺乳动物雷帕霉素靶蛋白（mammalian target of rapamycin）的活性。因此，Bin2可能是一种新型的涉及mTOR通路的基因，不仅对肿瘤发生至关重要，同时也与生育功能密切相关。