Identification of Potential Biomarkers for Improving the Precision of Early Detection of Steroid-induced Osteonecrosis of the Femoral Head. Identification of Potential Biomarkers for Improving the Precision of Early Detection of Steroid-induced Osteonecrosis of the Femoral Head

Early diagnosis and prompt treatment are the key to prevent collapse and delay Steroid-induced Osteonecrosis of the Femoral Head(SONFH) progression.The aim of this study was to identify potential biomarkers for the diagnosis of SONFH, so to improve the efficiency of early diagnosis. Microarray analysis based on the 30 SONFH patients and 10 non-SONFH patients(following steroid administration) was performed to screen SONFH-related genes. Overall design: The aim of this study was to identify potential biomarkers for the diagnosis of SONFH. The gene expression profile was detected by microarray analysis based on the 30 SONFH patients and 10 non-SONFH patients. Then, a list of candidate gene biomarkers of SONFH were identified by integrating differential expression data analysis and gene signal transduction network analysis.

早期诊断与及时治疗是预防类固醇诱导性股骨头坏死（Steroid-induced Osteonecrosis of the Femoral Head，SONFH）塌陷、延缓其病情进展的关键。本研究旨在筛选可用于SONFH诊断的潜在生物标志物，以提升早期诊断效率。本研究纳入30例SONFH患者与10例经类固醇给药后的非SONFH患者，通过微阵列分析筛选与SONFH相关的基因。
整体实验设计：本研究的核心目标为筛选可用于SONFH诊断的潜在生物标志物。研究基于上述30例SONFH患者与10例经类固醇给药后的非SONFH患者，通过微阵列分析检测基因表达谱。随后，通过整合差异表达数据分析与基因信号转导网络分析，筛选得到SONFH候选基因生物标志物集。