1-microsecond trajectory of the E. coli FtsWI complex

We simulated the dynamics of an AlphaFold2-generated model of the E. coli FtsQLBWI divisome complex. Simulations reveal the importance of FtsQLB on stabilizing FtsWI in an active-like state, the role of the bound activator FtsN, and the effects of various superfission and dominant negative mutations on important interfaces formed within the complex.

本研究模拟了由阿尔法折叠2（AlphaFold2）生成的大肠杆菌（E. coli）FtsQLBWI分裂体复合物的动力学特性。模拟结果揭示了FtsQLB在将FtsWI稳定于类激活状态中的关键作用、结合型激活因子FtsN的功能，以及各类超分裂突变与显性负效突变对该复合物内部形成的重要相互作用界面的影响。