Palladium(II)-Catalyzed Mono- and Bis-alkenylation of N‑Acetyl-2-aminobiaryls through Regioselective C–H Bond Activation

We developed palladium-catalyzed oxidative coupling of olefins with N-acyl 2-aminobiaryls through a sequence of ortho C–H bond activation/alkene insertion/reductive elimination. Furthermore, we controlled the selectivity of mono- and bis-alkenylation products with the solvent effect. The developed protocol was promising for a broad substrate scope ranging from activated olefins with a wide variety of functional groups to unactivated olefins.本研究开发了一种通过邻位C-H键活化/烯烃插入/还原消除序列实现的钯催化烯烃与N-酰基2-氨基联芳烃的氧化偶联反应。此外，本研究借助溶剂效应实现了单烯基化与双烯基化产物的选择性调控。所开发的合成方法具有良好的底物普适性，其底物范围涵盖带有各类官能团的活化烯烃以及非活化烯烃。