Analysis of possible mechanisms behind functional recovery following neural progenitor cell transplantation into spinal cord injury.

Long-term survival and integration of neural progenitor cells (NPCs) transplanted following spinal cord injury (SCI) have been observed. However, questions concerning the differentiation choice of NPCs, their mechanism of action and their contribution to functional recovery remains unanswered. Therefore, we investigated global transcriptomal changes in transplanted NPCs transplanted into SCI. We found that NPCs transplanted into SCI up-regulate genes related to nerve cell function and signaling and differentiation, and down-regulate genes related to cytokine signaling and apoptosis. Overall design: Stem cells transplantation in spinal cord injury in rodents

脊髓损伤（spinal cord injury, SCI）后移植的神经前体细胞（neural progenitor cells, NPCs）的长期存活与整合已被观测到。然而，有关NPCs的分化选择、其作用机制以及其对功能恢复的贡献等诸多问题仍未得到解答。因此，本研究针对移植入SCI损伤部位的NPCs的全转录组变化展开了探究。研究结果显示，移植入SCI损伤部位的NPCs会上调与神经细胞功能、信号传导及分化相关的基因表达，同时下调与细胞因子信号传导及细胞凋亡相关的基因表达。实验整体设计：啮齿类动物脊髓损伤模型中的干细胞移植实验。