Summary of copy number variations detected in 157 samples of patients with severe obesity.

Control frequency refers to the frequency of the same type of rearrangement, deletion or duplication, in the control cohort (9,820 subjects). Progenitor phenotype refers only to the progenitor carrying the alteration. Hg19 assembly. F: female; M: male; Mat: maternal; Pat: paternal; N: normal; OW: overweight; OB: obesity; NA: not available; +: description of a mouse model with a phenotype related to body mass index (S1 Table). The genes interrupted at any of the breakpoints of the CNV are shown in boldface.对照频率指对照队列（共9820名受试者）中同一类型的重排、缺失或重复事件的发生频率。祖细胞表型仅指代携带该遗传变异的祖细胞。本研究采用Hg19基因组组装版本（Hg19 assembly）。缩写及符号说明：F：女性（female）；M：男性（male）；Mat：母系（maternal）；Pat：父系（paternal）；N：正常（normal）；OW：超重（overweight）；OB：肥胖（obesity）；NA：无可用数据（not available）；+：与体重指数相关表型的小鼠模型描述信息（详见附表S1）。在拷贝数变异（Copy Number Variant, CNV）的任一断点处发生中断的基因均以粗体格式标注。