Quantitative proteomic characterization of Foreign Body Response towards silicone breast implants identifies chronological disease-relevant biomarker dynamics

The aim of this work was to enlighten the disease progression from implant insertion and immediate tissue damage response reflected in (a) the acute wound proteome, and (b) the adsorption of chronic inflammatory wound proteins at implant surfaces. An intra-individual relative quantitation TMT-liquid chromatography-tandem mass spectrometry approach was applied to profile wound proteome formed around SMI the first five days post-implantation.本研究旨在阐明植入物植入及即时组织损伤应答过程中所反映的疾病进程，具体体现在两个方面：(a) 急性伤口蛋白质组；(b) 植入物表面吸附的慢性炎症伤口蛋白质。本研究采用个体内相对定量串联质量标签（TMT）-液相色谱-串联质谱方法，对植入后前5天内围绕SMI形成的伤口蛋白质组进行表征分析。