Additional file 1: of H3K27 acetylation and gene expression analysis reveals differences in placental chromatin activity in fetal growth restriction

Table S1. Differentially acetylated regions in FGR compared to controls. Table S2. Genes annotated to hyper- and hypoacetylated sites in placenta of FGR using a 20-kb window. Table S3. Functional pathways related to hypo- and hyperacetylated in placenta of FGR identified by GREAT. Table S4. Up- and downregulated gene transcripts in placenta of FGR compared to controls. Table S5. RNA-seq pathways TOPPfunn. Table S6. Functional pathways related to overlapping genes in CHIP-seq and RNA-seq. Table S7. AME output: differentially acetylated TFBMâ s in placenta of FGR vs. controls and functional pathways related to differentially acetylated TFBM (XLSX 694 kb)

附表S1：与对照组相比，胎儿生长受限（Fetal Growth Restriction, FGR）样本中的差异乙酰化区域。
附表S2：采用20千碱基（20-kb）窗口分析，注释胎儿生长受限（FGR）胎盘组织中高乙酰化与低乙酰化位点的基因。
附表S3：通过GREAT工具鉴定得到的胎儿生长受限（FGR）胎盘组织中与低乙酰化、高乙酰化区域相关的功能通路。
附表S4：与对照组相比，胎儿生长受限（FGR）胎盘组织中上调与下调的基因转录本。
附表S5：基于RNA测序（RNA-seq）通路的TOPPfunn分析结果。
附表S6：与染色质免疫沉淀测序（CHIP-seq）和RNA测序（RNA-seq）共有的重叠基因相关的功能通路。
附表S7：AME工具输出结果：胎儿生长受限（FGR）胎盘组织中相较于对照组的差异乙酰化转录因子结合基序（Transcription Factor Binding Motifs, TFBM），以及与差异乙酰化转录因子结合基序相关的功能通路（XLSX格式，大小694 kb）