Impact of Sphingosine Kinase-1 knock out in neonatal mice lungs

Sphingosine Kinase-1 knock out protects against hyperoxic lung injury One day old Wild type (WT) control and Sphingosine Kinase-1 knock out (SphK-1 KO)pups exposed to room air (RA) or hyperoxia (HO). Microarray based profiling of lung tissue after 7 days of hyperoxia of 75% WT RA, WT HO, SphK-1 KO RA, and Sph K-1 KO HO studied in triplicates鞘氨醇激酶1（Sphingosine Kinase-1，SphK-1）敲除可对抗高氧性肺损伤。本数据集以1日龄野生型（Wild type，WT）对照幼鼠及鞘氨醇激酶1敲除幼鼠为实验对象，将其分别暴露于常压空气（Room air，RA）及高氧环境（Hyperoxia，HO）中。针对经75%氧浓度高氧暴露7天后的肺组织，采用基于微阵列（Microarray）的技术进行表达谱分析，所涉样本分为四组：WT RA组、WT HO组、SphK-1 KO RA组及SphK-1 KO HO组，每组均完成三次重复实验。