Table_3_Resting-State Electroencephalography Functional Connectivity Networks Relate to Pre- and Postoperative Language Functioning in Low-Grade Glioma and Meningioma Patients.DOCX

Introduction: Preservation of language functioning in patients undergoing brain tumor surgery is essential because language impairments negatively impact the quality of life. Brain tumor patients have alterations in functional connectivity (FC), the extent to which brain areas functionally interact. We studied FC networks in relation to language functioning in glioma and meningioma patients. Method: Patients with a low-grade glioma (N = 15) or meningioma (N = 10) infiltrating into/pressing on the language-dominant hemisphere underwent extensive language testing before and 1 year after surgery. Resting-state EEG was registered preoperatively, postoperatively (glioma patients only), and once in healthy individuals. After analyzing FC in theta and alpha frequency bands, weighted networks and Minimum Spanning Trees were quantified by various network measures. Results: Pre-operative FC network characteristics did not differ between glioma patients and healthy individuals. However, hub presence and higher local and global FC are associated with poorer language functioning before surgery in glioma patients and predict worse language performance at 1 year after surgery. For meningioma patients, a greater small worldness was related to worse language performance and hub presence; better average clustering and global integration were predictive of worse outcome on language function 1 year after surgery. The average eccentricity, diameter and tree hierarchy seem to be the network metrics with the more pronounced relation to language performance. Discussion: In this exploratory study, we demonstrated that preoperative FC networks are informative for pre- and postoperative language functioning in glioma patients and to a lesser extent in meningioma patients.研究背景：脑肿瘤手术患者的语言功能保留至关重要，因为语言障碍会对生活质量产生负面影响。脑肿瘤患者的大脑功能连接（functional connectivity, FC）——即脑区间功能交互的程度——存在异常改变。本研究针对胶质瘤（glioma）与脑膜瘤（meningioma）患者，探究其功能连接网络与语言功能的关联。 研究方法：本研究纳入15例低级别胶质瘤（low-grade glioma）、10例脑膜瘤患者，上述肿瘤均浸润或压迫语言优势半球；所有患者均在术前及术后1年接受全面的语言功能评估。研究采集了所有受试者的静息态脑电图（resting-state EEG）：术前各采集一次，术后仅胶质瘤患者额外采集一次，健康对照人群仅采集一次。在分析θ频段与α频段的功能连接后，通过多种网络量化指标对加权网络与最小生成树（Minimum Spanning Trees）进行分析量化。 研究结果：胶质瘤患者术前的功能连接网络特征与健康人群无显著差异。但在胶质瘤患者中，枢纽节点存在性以及更高的局部与全局功能连接，与术前较差的语言功能相关，同时可预测术后1年的语言表现更差。对于脑膜瘤患者而言，更高的小世界属性（small worldness）与枢纽节点存在性均与较差的语言表现相关；更高的平均聚类系数与全局整合水平，则可预测术后1年语言功能结局更差。平均偏心度、网络直径与树层级结构，是与语言表现关联最为显著的网络指标。 讨论：本探索性研究表明，术前功能连接网络可有效反映胶质瘤患者术前及术后的语言功能状态，而对脑膜瘤患者的预测价值相对较弱。