single_trial_analysis_psychometric: processed single trial data for psychometric task

Dopaminergic action prediction errors serve as a value-free teaching signalAnimals’ choice behavior is characterized by two main tendencies: taking actions that led to rewards and repeating past actions. Theory suggests these strategies may be reinforced by different types of dopaminergic teaching signals: reward prediction error to reinforce value-based associations and movement-based action prediction errors to reinforce value-free repetitive associations. Here we use an auditory-discrimination task in mice to show that movement-related dopamine activity in the tail of the striatum encodes the hypothesized action prediction error signal. Causal manipulations reveal that this prediction error serves as a value-free teaching signal that supports learning by reinforcing repeated associations. Computational modelling and experiments demonstrate that action prediction errors alone cannot support reward-guided learning but when paired with the reward prediction error circuitry they serve to consolidate stable sound-action associations in a value-free manner. Together we show that there are two types of dopaminergic prediction errors that work in tandem to support learning, each reinforcing different types of association in different striatal areas.These data are the result of pre processing of psychometric per trial photometry and behavioral data.Produced by code in https://github.com/SainsburyWellcomeCentre/SJLab_APE_paper/tree/main/APE_paper_photometry_code_francescafiles:<i>figure4/reformat_psychometric_data.py</i><br>

多巴胺能动作预测误差（dopaminergic action prediction errors）作为一种无价值教学信号。动物的选择行为具有两大核心倾向：一是采取曾带来奖赏的行动，二是重复过往行为。现有理论提出，这两类策略可通过不同类型的多巴胺能教学信号进行强化：奖赏预测误差（reward prediction error）用于强化基于价值的联结，而动作预测误差（action prediction error）则用于强化无价值的重复性联结。本研究借助小鼠听觉辨别任务（auditory-discrimination task），证实纹状体尾部（tail of the striatum）中与动作相关的多巴胺活动，可编码假说中的动作预测误差信号。因果操控实验表明，该预测误差作为一种无价值教学信号，通过强化重复性联结来支撑学习过程。计算建模与实验结果显示，仅靠动作预测误差无法支持奖赏导向的学习，但当其与奖赏预测误差环路相结合时，便可通过无价值的方式巩固稳定的声音-动作联结。综上，本研究证实存在两类协同发挥作用的多巴胺能预测误差，它们分别在不同的纹状体区域强化不同类型的联结。本数据集为逐试次心理物理学光度学与行为学数据的预处理结果。数据生成代码位于：https://github.com/SainsburyWellcomeCentre/SJLab_APE_paper/tree/main/APE_paper_photometry_code_francescafiles，具体脚本为<i>figure4/reformat_psychometric_data.py</i>