Effect of deficiency of PINK1 on gene expression during 4-month and 24-month.. Effect of deficiency of PINK1 on gene expression during 4-month and 24-month.

To investigate the PINK1 regulates mitochondrial function, we performed the gene expression data for two independent libraries for Pink1-/- and Pink1+/+ mice, at two different time points, 4 and 24 months. Overall design: Comparative gene expression profiling analysis of RNA-seq data for 4month and 24-month mice in Pink1+/+ and Pink1-/- mice.

为探究PINK1对线粒体功能的调控作用，我们针对Pink1纯合敲除（Pink1-/-）与野生型（Pink1+/+）小鼠的两个独立文库，在4月龄与24月龄两个时间点开展了基因表达数据分析。整体实验设计：对Pink1+/+及Pink1-/-小鼠在4月龄与24月龄时的RNA测序（RNA-seq）数据进行比较基因表达谱分析。