Quality of life perception of type 1 diabetic patients treated with insulin analogs and receiving medication review with follow-up in a public health care service from Ponta Grossa-PR, Brazil

ABSTRACT Glycemic control in patients with diabetes mellitus type 1 (DM1) reduces the risk of complications but requires a rigorous health care routine. Thus, diabetes education is central to increasing treatment compliance and self-care practices. This study aimed to evaluate the quality of life (QoL) and glycemic control of DM1 patients being treated with insulin analogs and receiving medication review with follow-up. This was a transversal study that included 110 patients registered at the 3rd Health Regional of Ponta Grossa-PR, aged ≥ 18 years, and receiving pharmaceutical care for at least 1 year. The Diabetes Quality of Life Measure (DQOL)-Brazil was used to evaluate QoL. The data were statistically analyzed using SPSS version 17.0 with 95% confidence levels. Of the 110 patients, 58.2% were women. The average age was 33.7 years (±10.5), and the average glycated hemoglobin (HbA1c) value was 8% (±1.4). The mean total DQOL-Brazil score was 2.11 (95% confidence interval, 2.02 - 2.21). All DQOL-Brazil scores were lower in patients with HbA1c ≤ 8%, indicating a better QoL. Good glycemic control, thus, appears to have a positive influence on the QoL, and pharmaceutical interventions are able to contribute to the achievement of therapeutic targets.

摘要：1型糖尿病（diabetes mellitus type 1，DM1）患者的血糖控制可降低并发症风险，但需严格遵循医疗照护流程。因此，糖尿病健康教育对于提升治疗依从性与自我护理行为至关重要。本研究旨在评估接受胰岛素类似物治疗，并接受带随访的用药审核的1型糖尿病患者的生命质量（quality of life，QoL）与血糖控制情况。本研究为横断面研究，纳入了巴西巴拉那州蓬塔格罗萨第三卫生区域登记的110名患者，所有受试者年龄≥18岁，且接受药学服务至少1年。本研究采用糖尿病生命质量量表（Diabetes Quality of Life Measure，DQOL）-巴西版评估患者的生命质量。数据采用SPSS 17.0版本进行统计学分析，置信水平设为95%。在110名受试者中，58.2%为女性；平均年龄为33.7岁（±10.5），平均糖化血红蛋白（glycated hemoglobin，HbA1c）值为8%（±1.4）；DQOL-巴西版总均分均值为2.11（95%置信区间：2.02~2.21）。糖化血红蛋白≤8%的患者各项DQOL-巴西版评分均更低，提示其生命质量更优。综上，良好的血糖控制似乎对生命质量具有积极影响，而药学干预能够助力达成治疗目标。