Cleaned dataset for PubChem AID 1347031: qHTS assay of progesterone receptor (PR) antagonists

This dataset is derived from PubChem BioAssay AID 1347031, titled "Progesterone receptor (PR) small molecule antagonists, qHTS assay: Summary". The original assay is part of the Tox21 program and evaluates inhibition of progesterone receptor (PR) signaling using a beta-lactamase reporter assay in HEK293 cells engineered with a PR-responsive reporter system. Original dataset statistics: - Tested compounds: 7,671 - Active (antagonists): 861 - Inactive: 5,723 Data preprocessing: - Removed duplicate entries based on compound identifiers. - Resolved conflicting labels by excluding compounds with inconsistent activity annotations. Final cleaned dataset: - Total compounds: 6,250 - Positive (antagonists): 760 - Negative (inactive): 5,490本数据集源自PubChem BioAssay编号AID 1347031，标题为“孕激素受体（PR）小分子拮抗剂qHTS检测：总结。 该原始检测隶属于Tox21计划，采用经PR响应报告系统改造的HEK293细胞，通过β-内酰胺酶报告基因检测法评估孕激素受体信号通路的抑制活性。 原始数据集统计信息： - 受试化合物：7671种，活性（拮抗剂）：861种，无活性：5723种 数据预处理环节： - 基于化合物标识符去除重复条目；排除活性标注不一致的化合物以解决标签冲突。 最终清洗完成的数据集： - 总化合物数：6250种 - 阳性（拮抗剂）：760种 - 阴性（无活性）：5490种