Transcriptomic analysis of T84 colon carcinoma cell line treated with trametinib, JQ1 or their combination

T84 cells were treated with DMSO, 30nM trametinib (MEKi), 1µM JQ1 (BRD4i) or the combination of trametinib and JQ1 (combo) for 24h. 3 replicates per condition were analyzed by RNA-seq.将T84细胞分别经二甲基亚砜（DMSO）、30nM曲美替尼（trametinib，MEK抑制剂，MEKi）、1µM JQ1（BRD4抑制剂，BRD4i）或曲美替尼与JQ1的联合处理组（combo）处理24小时。每个实验条件设置3次生物学重复，采用RNA测序（RNA-seq）进行分析。