00f152c4-86f2-4e31-8af5-c03e6ff37ea6 - samples

Formalin-fixed, paraffin-embedded samples from 643 colorectal adenomas collected in different hospitals in Norway, from which DNA was extracted, were analysed for DNA copy number alterations. Some adenomas had more than one block (n=42), thus 643 individuals, 685 blocks. Low-coverage whole genome sequencing was run in all samples. For 529 individuals all the clinical information was available. A subset was matched for follow-up time, age and sex in a nested case-control approach (n=366; cases - individuals who developed later on CRC; controls - individuals who did not develop CRC within the same follow-up time).EGA dataset EGAD00001010119

本数据集包含挪威不同医院收集的643例结直肠腺瘤福尔马林固定石蜡包埋（Formalin-fixed, paraffin-embedded）样本，其中42例腺瘤对应多个组织块，最终共计643名受试者、685个组织块。从上述样本中提取脱氧核糖核酸（DNA）后，对其DNA拷贝数变异进行了分析。所有样本均完成低覆盖度全基因组测序。其中529名受试者的完整临床信息均可获取。研究采用巢式病例对照研究（nested case-control approach）设计，按随访时间、年龄及性别进行匹配，筛选出366例样本：病例组为后续发展为结直肠癌（colorectal cancer, CRC）的受试者，对照组为同期随访周期内未发生结直肠癌的受试者。本数据集为欧洲基因组学档案（EGA）数据集EGAD00001010119。