Table_2_Association of the rs1990760, rs3747517, and rs10930046 polymorphisms in the IFIH1 gene with susceptibility to autoimmune diseases: a meta-analysis.docx

ObjectiveInterferon induced with helicase C domain 1 (IFIH1) single-nucleotide polymorphisms (SNP) rs1990760, rs3747517, and rs10930046 have been shown to be closely related to the risk of autoimmune diseases. The aim of this study was firstly to examine the association of the rs1990760 with type 1 diabetes (T1D) in a Chinese population. Secondly, to assess the association of SNP rs1990760, rs3747517, and rs10930046 with autoimmune diseases susceptibility.MethodsA total of 1,273 T1D patients and 1,010 healthy control subjects in a Chinese population were enrolled in this case-control study. Subsequently, we performed a meta-analysis on the association of the SNP rs1990760, rs3747517, and rs10930046 in the IFIH1 gene with susceptibility to autoimmune diseases. The random and fixed genetic effects models were used to evaluate the association and the effect sizes, including odds ratios (OR) and 95% confidence intervals (CI). Stratification analyses based on ethnicity and the type of autoimmune diseases were performed.ResultsIFIH1 SNP rs1990760 was not associated with a significant risk of T1D in the Chinese population in the case-control study. A total of 35 studies including 70,966 patients and 124,509 controls were identified and included in the meta-analysis. The results displayed significant associations between IFIH1 rs1990760 A allele and rs3747517 C allele and autoimmune diseases risk (OR=1.09, 95% CI: 1.01~1.17; OR=1.24, 95% CI: 1.15~1.25, respectively). Stratified analysis indicated a significant association rs1990760 and rs3747517 with autoimmune diseases risk in the Caucasian population (OR=1.11, 95% CI: 1.02~1.20, OR=1.29, 95% CI: 1.18~1.41, respectively).ConclusionsThis study revealed no association between IFIH1 SNP rs1990760 and T1D in Chinese. Furthermore, the meta-analysis indicated that rs1990760 and rs3747517 polymorphisms, confer susceptibility to autoimmune diseases, especially in the Caucasian population.

旨在探究IFIH1基因中的单核苷酸多态性（SNP）rs1990760、rs3747517和rs10930046与自身免疫性疾病风险的相关性，本研究首先旨在评估rs1990760与我国汉族人群1型糖尿病（T1D）风险之间的关联，其次，评估上述SNP与自身免疫性疾病易感性的关联。研究方法：纳入我国1型糖尿病患者1273例及健康对照者1010例，对IFIH1基因中上述SNP与自身免疫性疾病易感性的关联进行了荟萃分析，采用随机效应模型和固定效应模型评估关联及其效应量，包括比值比（OR）和95%置信区间（CI）。基于种族和自身免疫性疾病类型进行的分层分析结果显示：在病例对照研究中，IFIH1基因SNP rs1990760与我国汉族人群T1D风险无显著关联。荟萃分析共纳入35项研究，包括70,966名患者和124,509名对照者，结果显示IFIH1基因rs1990760 A等位基因与rs3747517 C等位基因与自身免疫性疾病风险存在显著关联（OR=1.09，95%CI: 1.01~1.17；OR=1.24，95%CI: 1.15~1.25，分别）。分层分析显示，在白种人群中，rs1990760和rs3747517多态性与自身免疫性疾病风险存在显著关联（OR=1.11，95%CI: 1.02~1.20，OR=1.29，95%CI: 1.18~1.41，分别）。结论：本研究未发现IFIH1基因SNP rs1990760与我国汉族人群T1D之间存在关联。进一步荟萃分析表明，rs1990760和rs3747517多态性增加了自身免疫性疾病的风险，尤其在白种人群中。