Additional file 1: of Effects of PKM2 on global metabolic changes and prognosis in hepatocellular carcinoma: from gene expression to drug discovery

Table S1. Differentially expressed genes in high-PKM2 group. Table S2. Differentially expressed genes in low-PKM2 group. Table S3. Descriptive statistics of PKM2 and other clinical features grouped by hierarchical clustering. Table S4. Multivariate logistic regression between PKM2 and hierarchical clustering groups with adjusted covariates. Table S5. Details of gene set enrichment analysis in high-PKM2 vs. controls, low-PKM2 vs. controls and high-PKM2 vs. low-PKM2. Table S6. Correlation between PKM2 and metabolic genes in high-PKM2 group. Table S7. Correlation between PKM2 and metabolic genes in low-PKM2 group. Table S8. Survival analysis of up-regulated and PKM2-positively correlated metabolic genes. Table S9. Survival analysis of down-regulated and PKM2-negatively correlated metabolic genes. Table S10. Interaction of PKM2 and PKM2-uncorrelated metabolic genes on patientsâ overall survival. Table S11. Transcriptional regulation relationships of key metabolic genes. Table S12. Information of key metabolic genes and drugs. Table S13. Predicted compounds that affect risk metabolic genes by L1000CDS2 web tools. (XLSX 794 kb)

表S1 高PKM2组差异表达基因
表S2 低PKM2组差异表达基因
表S3 按分层聚类分组的PKM2及其他临床特征的描述性统计量
表S4 纳入调整协变量后，PKM2与分层聚类组间的多因素logistic回归分析结果
表S5 高PKM2组vs.对照组、低PKM2组vs.对照组及高PKM2组vs.低PKM2组的基因集富集分析详情
表S6 高PKM2组内PKM2与代谢基因的相关性分析结果
表S7 低PKM2组内PKM2与代谢基因的相关性分析结果
表S8 上调且与PKM2正相关的代谢基因的生存分析结果
表S9 下调且与PKM2负相关的代谢基因的生存分析结果
表S10 PKM2与不与PKM2相关的代谢基因对患者总生存期的交互作用
表S11 关键代谢基因的转录调控关系
表S12 关键代谢基因与药物的相关信息
表S13 经L1000CDS2在线工具预测的可影响风险代谢基因的化合物（XLSX 794 kb）