Parkinson's Anxiety Network (anxiety-network-pd)

An a priori anxiety network, based on previously reported results in structural and microstructural Parkinson’s disease anxiety literature. This network will be used in a region of interest analysis in a neuroimaging study characterising the microstructural basis of anxiety in early Parkinson's disease. It will be used alongside a High Density Anxiety Network (10.5281/zenodo.17158446). This network was updated in September 2025 and replaced a previous version originally published in November 2024. Following advice from an advisory thesis committee, a systematic review of PD anxiety neuroannatomical literature was conducted to inform the network, replacing a previous narrative review. This resulted in small changes to the annatomical nodes of the network. The update includes the addition of the left inferior frontal gyrus (opercular and triangular part), bilateral medial orbital gyrus, left anteroventral nucleus of the thalamus, bilateral substantia nigra pars compacta and reticulata and ventral tegmental area. The left inferior frontal gyrus pars orbitalis was removed. All other regions remain the same.本研究基于已发表的帕金森病焦虑症结构与微观结构相关文献成果，构建了先验焦虑网络（a priori anxiety network）。 该网络将应用于一项旨在阐明早期帕金森病患者焦虑症微观结构基础的神经影像学研究的感兴趣区分析，并将与高密度焦虑网络（High Density Anxiety Network，10.5281/zenodo.17158446）协同使用。 该网络于2025年9月完成更新，取代了2024年11月首次发布的旧版本。根据论文顾问委员会的建议，研究团队针对帕金森病（Parkinson's Disease，简称PD）焦虑症神经解剖学相关文献开展了系统综述，以此为依据更新该网络，替代了此前采用的叙述性综述，最终仅对网络的解剖节点做出小幅调整。本次更新新增了左额下回（岛盖部与三角部）、双侧内侧眶回、左侧丘脑前腹侧核、双侧黑质致密部与网状部以及腹侧被盖区，同时移除了左额下回眶部，其余脑区均保持不变。