Supporting data for "The roles of C-C motif ligand 11 (CCL11) in hepatocellular carcinoma recurrence after liver surgery"

My study has unveiled the novel mechanisms underlying CCL11-mediated tumor recurrence after liver resection. First, CCL11 enhances the invasive capacity of HCC cells. Second, CCL11 promotes the anti-inflammatory functions of CCR5⁺CD206⁺M2-like macrophages. These combined effects of CCL11 ultimately lead to immune evasion and tumor recurrence after liver resection.本研究阐明了肝切除术后CCL11介导的肿瘤复发的全新机制。其一，CCL11可增强肝细胞癌（Hepatocellular Carcinoma, HCC）细胞的侵袭能力；其二，CCL11能够促进CCR5+CD206+M2样巨噬细胞的抗炎功能。CCL11的上述协同效应最终将引发免疫逃逸，并导致肝切除术后的肿瘤复发。