IMC Diabetes dataset (Damond et al.)

The IMC dataset generated by Damond et al. longitudinally profiles pancreatic tissue samples obtained from 67 human donors, including both non-diabetic individuals and patients diagnosed with Type 1 diabetes (T1D). The dataset is comprised of 33 non-diabetic controls and 34 donors with established long-standing T1D. Long-standing T1D represents patients with prolonged disease duration following diagnosis, typically characterized by sustained autoimmune-mediated β-cell depletion and chronic inflammatory remodeling of the pancreatic microenvironment. The IMC panel stained for 38 proteins.由Damond等人构建的IMC数据集（IMC）对67名人类供者的胰腺组织样本开展纵向特征谱分析，样本来源涵盖非糖尿病个体与确诊1型糖尿病（Type 1 diabetes, T1D）患者。该数据集包含33例非糖尿病对照样本与34例长期确诊T1D的供者样本。长期T1D指确诊后病程迁延的患者群体，其典型病理特征为持续的自身免疫介导的β细胞耗竭与胰腺微环境的慢性炎症重塑。该IMC检测面板针对38种蛋白完成免疫染色。