Prevalence of central venous catheter salvage in newborn with staphylococcal bloodstream infection

ABSTRACT Objectives: to establish the prevalence of salvage of central venous catheters in newborns with bloodstream infection caused by coagulase-negative staphylococci. Methods: retrospective cross-sectional study with 136 newborns admitted to the Neonatal Intensive Care Unit between 2011 and 2017. The total of 143 infection events undergoing antibiotic therapy were evaluated. Results: among the 143 infection events, 39 catheters in which antibiotic therapy was used were saved and in 69 cases, the device was removed. Positive central blood culture and single lumen catheter were factors associated with salvage failure. The probability of salvage decreased with infections diagnosed from 15 days of using the catheter. Negative blood culture raised the chance of salvage by fourfold. Conclusions: the use of antibiotic therapy in the treatment of infections resulted in a low prevalence of salvage of the central venous catheter. The probability of salvage was associated with variables of the device.

摘要

研究目的：明确凝固酶阴性葡萄球菌（coagulase-negative staphylococci）血流感染新生儿的中心静脉导管（central venous catheter, CVC）挽救治疗的现患率。

研究方法：本研究为回顾性横断面研究，纳入2011年至2017年入住新生儿重症监护病房（Neonatal Intensive Care Unit, NICU）的136例新生儿，对共计143例接受抗菌药物治疗的感染事件展开评估。

研究结果：143例感染事件中，39例接受抗菌药物治疗的导管得以挽救，69例病例移除了该中心静脉导管。中心血培养阳性与单腔导管（single lumen catheter）是导管挽救失败的相关危险因素。导管置入后15天确诊的感染，其导管挽救概率呈下降趋势。血培养阴性可使导管挽救的几率提升四倍。

研究结论：针对血流感染采用抗菌药物治疗时，中心静脉导管挽救治疗的整体现患率较低。导管挽救概率与导管相关变量存在显著关联。