Reference percentiles for carotid measures of subclinical atherosclerosis in children and adolescents – Data from the KiGGS study

<p>The dataset presents reference centile data for carotid intima-media thickness as well as four carotid stiffness parameters. The reference percentiles are based on data from the German Health Interview and Examination Survey for Children and Adolescents 2003-2006 (KiGGS). KiGGS started as a cross-sectional study conducted between 2003 and 2006 which was based on a nationally representative sample and aimed at obtaining comprehensive data on the health of children and adolescents aged 0 to 17 years living in Germany. Detailed information on study design and conduct has been published in peer reviewed journals as well as detailed papers on individual parameters. The documentation provides relevant references.</p><p>11 years later, KiGGS Wave 2 (2014-2017) was conducted as an interview and examination survey. Carotid sonography was attempted at follow-up (KiGGS2) in all 4,798 participants of the KiGGS cohort aged 14 to 28 years. Carotide intima-media thickness (CIMT) was successfully measured in 4,709 participants. Reference centiles for the distensibility coefficient, stiffness index ß, Young's elastic modulus and Peterson's elastic modulus were computed using data on 4,305 adolescents and young adults aged 14 to 28.</p>本数据集提供了颈动脉内膜中层厚度（carotid intima-media thickness）以及四项颈动脉僵硬度参数的参考百分位数数据。该参考百分位数数据源自2003-2006年德国儿童青少年健康访谈与检查调查（German Health Interview and Examination Survey for Children and Adolescents, KiGGS）。KiGGS作为一项横断面研究于2003至2006年间开展，依托全国代表性样本，旨在全面获取居住在德国的0至17岁儿童青少年的健康相关数据。有关研究设计与实施的详细信息已发表于同行评议期刊，各项参数的详细说明亦已发表专项论文，本次数据集文档亦提供了相关参考文献。 时隔11年，KiGGS Wave 2（2014-2017年版）作为访谈与检查调查项目顺利开展。研究团队对KiGGS队列中14至28岁的全部4798名参与者开展了随访阶段（KiGGS2）的颈动脉超声检查尝试，最终成功为4709名参与者完成了颈动脉内膜中层厚度（CIMT）检测。研究团队基于4305名14至28岁青少年与年轻成人的数据，计算得到了扩张系数、僵硬度指数β、杨氏弹性模量以及彼得森弹性模量的参考百分位数。