STAT1 and Head and Neck Cancer. STAT1 and Head and Neck Cancer

This study examines the role of host STAT1 expression during oral carcinogenesis using an orthotopic model of metastatis oral cancer. Overall design: LY2 oral cancer cell lines were injected into the oral cavity of WT or Stat1 deficient BALB/C mice. Tumors were subjected to bulk RNA sequencing

本研究采用转移性口腔癌原位模型，解析宿主STAT1表达在口腔癌变进程中的作用。实验整体设计：将LY2口腔癌细胞系分别接种于野生型（WT）及Stat1基因缺陷型BALB/C小鼠的口腔内，随后对获取的肿瘤样本开展批量RNA测序（bulk RNA sequencing）。