Computerized cognitive rehabilitation for patients with traumatic brain injury: A systematic review of randomized controlled trials

Cognitive impairments are among the most common sequences of patients with traumatic brain injury (TBI). Computerized cognitive rehabilitation uses multimedia and informatics resources to deliver cognitive training. This review aims to investigate the effects of computerized cognitive training in patients with TBI. PubMed, SCOPUS, MEDLINE, PEDro, Web of Science, REHABDATA, and EMBASE were searched from their inception until August 2023. The methodological quality was assessed using the Cochrane Collaboration tool. After screening 461 records, a total of six studies met the specified inclusion criteria and involved 270 participants (mean age 46.91 years), 41% of whom were female. The included studies exhibited “high” quality on the Cochrane Collaboration tool. There were improvements in various cognitive domains in patients with TBI following computerized cognitive training. Computerized cognitive training is a safe intervention for patients with TBI. The evidence for the effect of computerized cognitive training on patients with TBI is promising. Combining computerized cognitive training with other interventions may yield more beneficial effects in improving cognitive function in patients with TBI than computerized cognitive training alone. Additional studies with larger sample sizes and long-term follow-up are warranted.

认知障碍是创伤性脑损伤（traumatic brain injury，TBI）患者最常见的后遗症之一。计算机化认知康复借助多媒体与信息学资源开展认知训练。本综述旨在探究计算机化认知训练对创伤性脑损伤患者的干预效果。本次综述检索了PubMed、SCOPUS、MEDLINE、PEDro、Web of Science、REHABDATA及EMBASE数据库，检索时限自建库至2023年8月。采用Cochrane协作网（Cochrane Collaboration）偏倚风险评估工具对纳入研究的方法学质量进行评价。经初步筛选后共获取461条文献记录，最终纳入6项符合预设纳入标准的研究，涉及270名受试者（平均年龄46.91岁），其中女性占比41%。纳入研究在Cochrane协作网工具评分中均被评定为"高质量"。创伤性脑损伤患者在接受计算机化认知训练后，多项认知领域均获得显著改善。计算机化认知训练对创伤性脑损伤患者而言是一项安全的干预手段。现有证据表明，计算机化认知训练对创伤性脑损伤患者的干预效果颇具前景。相较于单独应用计算机化认知训练，将其与其他干预手段联合实施，或可更显著地改善创伤性脑损伤患者的认知功能。未来仍需开展更大样本量且包含长期随访的相关研究以进一步验证相关结论。