A Novel Tandem Sequence to Pyrrole Syntheses by 5-<i>endo</i>-<i>dig</i> Cyclization of 1,3-Enynes with Amines

The synthesis of pentasubstituted pyrroles has been described using molecular iodine from 1,3-enynes and amines via a sequential tandem aza-Michael addition, iodocyclization, and oxidative aromatization. The protocol is simple and efficient to afford the target products at ambient conditions.本研究报道了以分子碘为介导试剂，由1,3-烯炔与胺类化合物出发，通过氮杂迈克尔加成（aza-Michael addition）、碘环化（iodocyclization）及氧化芳构化（oxidative aromatization）串联反应合成五取代吡咯的方法。该合成方案简便高效，可在温和的环境条件下得到目标产物。