RNA sequencing analysis of rupture-prone intracranial aneurysms and the remaining circle of Willis in rats

Comprehensive gene expression profile was obtained by RNA sequencing analysis using total RAN purified from intracranial aneurysm lesions and remaining circle of Willis in rats. Overall design: Comparison of gene expression profile between an intracranial aneurysm lesion and the remaining circle of Willis from the same animal by RNA sequencing analysis of 3 rats.

本研究通过RNA测序（RNA sequencing）技术，对提取自大鼠颅内动脉瘤（intracranial aneurysm）病灶及剩余大脑动脉环（circle of Willis）的总RNA（total RNA）进行分析，成功获取了全面的基因表达谱。实验设计：选取3只大鼠，分别对其颅内动脉瘤病灶与同体剩余大脑动脉环开展RNA测序，对比二者的基因表达谱差异。