Nonclinical human neural new approach methodologies (NAMs): Electrophysiological assessment of opioid agonist and antagonist combination - Datasets

New approach methodologies (NAMs) including microphysiological systems in combination with human induced pluripotent stem cell (hiPSC)-derived neural cells and multielectrode array (MEA) have demonstrated utility for evaluating electrophysiological effects of CNS active compounds including those with potential seizurogenic liability. Here, we extend a neural NAM assay to assessment of an opioid agonist and reversal agent.

包括微生理系统在内的新型研究方法学（New Approach Methodologies，NAMs），联合人诱导多能干细胞（human induced pluripotent stem cell，hiPSC）源性神经细胞与多电极阵列（multielectrode array，MEA），已被证实可用于评估中枢神经系统（Central Nervous System，CNS）活性化合物的电生理效应，其中包括具有潜在致痫潜能的化合物。本研究将神经类NAM检测方法拓展应用于阿片受体激动剂及逆转剂的评价。