In vivo pharmacodynamics of bicyclic 4-nitroimidazole analogs studied in mice.

The mean log lung CFU’s in five independent invivo efficacy studies ranged between 6.07 and 6.66 in untreated infected mice.nd = not determined.ΔMean log lung CFU reduction compared to untreated controls. Each data represents mean value ± SEM from 5 animals.$Mean value from three independent experiments (n = 15).*Significant difference at PnsNo significant difference at P五项独立体内（in vivo）药效学研究结果显示，未予处理的感染小鼠的肺组织菌落形成单位（Colony-Forming Units, CFU）对数均值介于6.07至6.66区间内。 nd = 未测定（not determined）。 Δ：相较于未处理对照组的肺组织CFU对数降幅均值。 各数据均为5只实验动物的均值±标准误（Standard Error of the Mean, SEM）。 $：三项独立实验的均值（n=15）。 *：经P值检验存在显著差异；ns：无显著差异。