Curated Envirotox database and compound specific Human-Biota TTC from the LIFE+ Vermeer project

In the paper "Defining the Human-Biota Thresholds of Toxicological Concern for Organic Chemicals in Freshwater: The Proposed Strategy of the LIFE VERMEER Project Using VEGA Tools" by Baderna et al., 2021 (https://doi.org/10.3390/molecules26071928) we are proposing a strategy to define the Human-Biota TTCs (HB-TTCs) as concentrations of organic chemicals in freshwater preserving both humans and ecological receptors at the same time. Two sets of thresholds were derived: general HB-TTCs as preliminary screening levels for compounds with no eco- and toxicological information, and compound-specific HB-TTCs for chemicals with known hazard assessment, in terms of Predicted No effect Concentration (PNEC) values for freshwater ecosystems and acceptable doses for human health. The proposed strategy is based on freely available public data and tools to characterize and group chemicals according to their toxicological profiles. Five generic HB-TTCs were defined, based on the ecotoxicological profiles reflected by the Verhaar classes, and compound-specific thresholds for more than 400 organic chemicals with complete eco- and toxicological profiles. The list of &gt;400 compound-specific HB-TTC is included in this dataset. <strong>This work was funded by the LIFE+ Projects VERMEER [LIFE16/ENV/IT/000167] and was conducted under the framework of the Italian Institute For Planetary Health (IIPH).</strong> <em><strong>reference: </strong></em>Baderna D, Faoro R, Selvestrel G, Troise A, Luciani D, Andres S, Benfenati E. Defining the Human-Biota Thresholds of Toxicological Concern for Organic Chemicals in Freshwater: The Proposed Strategy of the LIFE VERMEER Project Using VEGA Tools. <em>Molecules</em>. 2021; 26(7):1928. <strong>https://doi.org/10.3390/molecules26071928</strong>在Baderna等人2021年发表的论文*《淡水有机化学品的人类-生物群毒性关注阈值定义：基于VEGA工具的LIFE VERMEER项目拟议策略》*（DOI：https://doi.org/10.3390/molecules26071928）中，研究团队提出了一套用于定义人类-生物群毒性关注阈值（Human-Biota TTCs, HB-TTCs）的策略，该阈值指同时保障人类与生态受体安全的淡水有机化学品浓度限值。 研究共推导得到两类阈值：通用型HB-TTCs，作为无生态与毒理学信息化学品的初步筛选水平；以及化合物专属型HB-TTCs，适用于具备完整危害评估数据的化学品，其评估依据为淡水生态系统的预测无效应浓度（Predicted No effect Concentration, PNEC）与保障人体健康的可接受暴露剂量。 本策略依托免费公开的数据与工具，可根据化学品的毒理学特征对其进行表征与分类。研究基于Verhaar分类法所体现的生态毒理学特征，定义了5类通用型HB-TTCs，并为400余种具备完整生态与毒理学特征的有机化学品制定了化合物专属阈值。 本数据集收录了超过400项化合物专属型HB-TTCs的相关列表。 **本研究由LIFE+计划VERMEER项目[LIFE16/ENV/IT/000167]资助，并依托意大利行星健康研究所（Italian Institute For Planetary Health, IIPH）的框架开展。** *参考引文：* Baderna D, Faoro R, Selvestrel G, Troise A, Luciani D, Andres S, Benfenati E. *《淡水有机化学品的人类-生物群毒性关注阈值定义：基于VEGA工具的LIFE VERMEER项目拟议策略》*. *Molecules*. 2021; 26(7):1928. https://doi.org/10.3390/molecules26071928