Data from PhD thesis by Danijela Bogdanovic "Towards a new Era of Fracture Fixation - Photopolymerizable Bone Adhesives based on Thiol-Ene Chemistry"

Context and methodology

This data was collected within the framework of the PhD thesis by Danijela Bogdanovic. The thesis has been deposited in TU Wien's reposiTUm . The data is currently restricted. The thesis aimed for further exploration and optimization of photopolymerizable bone adhesives, particularly with regard to their degradability and biocompatibility. 

The thesis comprises three main chapters, which describe in the following order: 1.) the improvement of the adhesion strength under wet conditions; 2.) the enhancement of the biodegradability of the matrix monomers; and 3.) the improvement of biocompatibility through the establishment of porous structures.

The first chapter covers the synthesis of new primer molecules as well as experimental data obtained from shear-bond-strength measurements. The second chapter describes the synthesis of alternative ene- monomers and the evaluation of their potential as degradable monomers in the final bone adhesive formulation. The third chapter describes the process of producing porous bone adhesives. 

Technical details

The data set is organized in several files/folders as described below.

PPTX file “Artwork_Danijela_Bogdanovic” contains all created images used in the abstract, introduction and summary of the thesis.

PPTX file “Visualized_data_Danijela_Bogdanovic” contains all processed and visualized data.

PPTX file “Compounds_Danijela_Bogdanovic” contains all synthesized substances and their shortcuts for easier assignment of the NMR files and other datasets.

Folder “NMR_raw_data” (ZIP) contains raw data of the substances referenced in the PPTX file “Compounds_Danijela_Bogdanovic” in following subfolders:

·       “Primer molecule” (substances from chapter 1.1)

·       “Wet adhesion” (substances from chapter 1.4)

·       “Degradable matrix ene-monomers” (substances from chapter 2.1 and 2.2)

Folder “Raw_data” (ZIP) contains the following data sets:

·       XLSX file “SBS_measurements_raw_data” contain all data sets (single measurements) from performed SBS-measurements from chapters 1,2 and 3.

·       XLSX file “Degradation_raw_data” contains the raw data from the performed degradation study, described in chapter 3.2.

·       XLSX file “Photorheo_raw_data” contains the data sets from photorheology studies described in chapter 2.2.

Folder “SEM_images” (ZIP) contains images in following subfolders:

·       “BoneAdh_Matrix_fiber_interaction” contains all SEM-images performed for evaluation of the fiber-matrix interface

·       “ES_PVA_and_PVA_Norb_20%” contains all SEM-images performed for visualization of electrospun PVA and PVA-Norb fibers from a 20 wt% aqu. solution

·       “ES_PVA_and_PVA_Norb_25%” contains all SEM-images performed for visualization of electrospun PVA and PVA-Norb fibers from a 25 wt% aqu. solution

·       “SBS_pins_nofiber” contains all SEM-images performed for visualization of the pin surface of the bone adhesive after SBS-measurement

·       “SBS_pins_with fibers” contains all SEM-images of the pin surface of the bone adhesive containing electrospun PVA-Norb fibers after SBS-measurement

·       “specimens_with_fibers” contains SEM-images of bone adhesives containing PLA and PVA-fibers

File types:

·       Bruker NMR raw data directories (pdata, acqu, shimvalues, etc.): processable with MestreNova or Bruker TopSpin

研究背景与方法

本数据集基于Danijela Bogdanovic的博士论文研究框架采集所得。该论文已存入维也纳工业大学（TU Wien）的reposiTUm知识库，本数据集目前处于受限访问状态。

本论文旨在进一步探索并优化可光聚合骨粘合剂，重点关注其降解性能与生物相容性。

论文共包含三个核心章节，按以下顺序展开论述：1. 优化湿环境下的粘结强度；2. 提升基体单体的生物降解性能；3. 通过构建多孔结构改善生物相容性。

第一章围绕新型底涂分子的合成，以及剪切粘结强度（shear-bond-strength, SBS）测试所得的实验数据展开。第二章阐述了新型烯类单体的合成路径，以及其作为可降解单体在最终骨粘合剂配方中的应用潜力评估。第三章则介绍了多孔骨粘合剂的制备工艺。

技术细节

本数据集按以下结构组织为多个文件与文件夹：

名为"Artwork_Danijela_Bogdanovic"的PPTX文件包含了论文摘要、引言与总结中使用的全部自制插图。
名为"Visualized_data_Danijela_Bogdanovic"的PPTX文件包含了所有经处理与可视化的实验数据。
名为"Compounds_Danijela_Bogdanovic"的PPTX文件收录了所有合成化合物及其简称，以便于核磁共振波谱（Nuclear Magnetic Resonance, NMR）文件与其他数据集的关联匹配。

压缩文件夹"NMR_raw_data"（ZIP格式）包含"Compounds_Danijela_Bogdanovic"文件中提及的所有化合物的原始NMR数据，其下设有如下子文件夹：
· "Primer molecule"：对应第一章1.1节中的合成物质
· "Wet adhesion"：对应第一章1.4节中的合成物质
· "Degradable matrix ene-monomers"：对应第二章2.1与2.2节中的可降解基体烯类单体

压缩文件夹"Raw_data"（ZIP格式）包含以下数据集：
· 名为"SBS_measurements_raw_data"的XLSX文件收录了第一章、第二章与第三章中所有剪切粘结强度测试的原始单组测量数据。
· 名为"Degradation_raw_data"的XLSX文件包含了第三章3.2节所述降解实验的原始数据。
· 名为"Photorheo_raw_data"的XLSX文件收录了第二章2.2节所述光流变学研究的相关数据集。

压缩文件夹"SEM_images"（ZIP格式）包含扫描电子显微镜（Scanning Electron Microscope, SEM）图像，其下设有如下子文件夹：
· "BoneAdh_Matrix_fiber_interaction"：收录用于评估纤维-基体界面的全部SEM图像
· "ES_PVA_and_PVA_Norb_20%"：收录用于可视化20 wt%水溶液中电纺聚乙烯醇（Polyvinyl Alcohol, PVA）与PVA-Norb纤维的全部SEM图像
· "ES_PVA_and_PVA_Norb_25%"：收录用于可视化25 wt%水溶液中电纺PVA与PVA-Norb纤维的全部SEM图像
· "SBS_pins_nofiber"：收录剪切粘结强度测试后未添加纤维的骨粘合剂试件针状表面的全部SEM可视化图像
· "SBS_pins_with_fibers"：收录剪切粘结强度测试后添加电纺PVA-Norb纤维的骨粘合剂试件针状表面的全部SEM图像
· "specimens_with_fibers"：收录添加聚乳酸（Polylactic Acid, PLA）与PVA纤维的骨粘合剂试件的SEM图像

文件格式说明：
· 布鲁克（Bruker）NMR原始数据目录（包含pdata、acqu、shimvalues等文件）：可通过MestreNova或Bruker TopSpin软件进行处理。