Table_1_Global research trends on the links between gut microbiota and cancer immunotherapy: A bibliometric analysis (2012-2021).docx

BackgroundThere is a crosstalk between gut microbiota (GM) and cancer immunotherapy (CI). The purpose of this study is to use bibliometric analysis to identify the highly cited papers relating to GM/CI and explore the research status and development trends of the GM/CI research.
MethodsA literature search regarding GM/CI publications from 2012 to 2021 was undertaken on July 4, 2022. The article titles, journals, authors, institutions, countries, total citations, keywords, and other information were extracted from the Science Citation Index Expanded (SCIE) of Web of Science Core Collection (WoSCC). The Bibliometrix of R package and VOSviewer were used for bibliometric analysis.
ResultsA total of 665 papers were extracted. The number of papers has increased rapidly over the past decade, especially after 2018. The United States and China had the most publications and made great contributions to this field. Th5e Univ Texas MD Anderson Canc Ctr and Univ Paris Saclay were absolutely in the leading position in GM/CI. The most influential authors were Zitvogel L and Routy B. Frontiers in Immunology had the most publications and Science had the most total citations. Historical direct citation analysis explained the historical evolution in GM/CI. Highly cited papers and high-frequency keywords illustrated the current status and trends of GM/CI. Four clusters were identified and the important topics included the role of GM and antibiotics in CI, the methods of targeting GM to improve CI outcomes, the mechanism by which GM affects CI and the application of ICIs in melanoma. “Tumor microbiome”, “proton pump inhibitors” and “prognosis” may be the new focus of attention in the next few years.
ConclusionThis study filtered global publications on GM/CI correlation and analyzed their bibliometric characteristics, identified the most cited papers in GM/CI, and gained insight into the status, hotspots and trends of global GM/CI research, which may inform researchers and practitioners of future directions.

**背景** 肠道菌群（gut microbiota，GM）与癌症免疫治疗（cancer immunotherapy，CI）之间存在交互调控关系。本研究旨在通过文献计量分析，筛选出与GM/CI相关的高被引论文，并探究该领域的研究现状与发展趋势。

**方法** 本研究于2022年7月4日针对2012至2021年发表的GM/CI相关文献开展检索。从Web of Science核心合集（Web of Science Core Collection，WoSCC）的科学引文索引扩展版（Science Citation Index Expanded，SCIE）中提取文献标题、期刊、作者、机构、国家、总被引频次、关键词等信息。采用R语言包Bibliometrix与VOSviewer进行文献计量分析。

**结果** 本研究共提取得到665篇文献。近十年间，该领域文献发表量呈快速增长趋势，尤其在2018年后增长尤为显著。美国与中国的文献发表量位居全球前列，为该领域做出了重要贡献。德克萨斯大学MD安德森癌症中心与巴黎萨克雷大学在GM/CI领域处于绝对领先地位。该领域最具影响力的作者为Zitvogel L与Routy B。《免疫学前沿》（Frontiers in Immunology）的发文量最高，而《科学》（Science）的总被引频次最高。历史直接引文分析阐明了GM/CI领域的研究演进历程。高被引论文与高频关键词则揭示了该领域的当前研究现状与发展趋势。本研究共识别出4个研究集群，核心研究主题包括：肠道菌群与抗生素在癌症免疫治疗中的作用、靶向肠道菌群以改善癌症免疫治疗疗效的方法、肠道菌群影响癌症免疫治疗的作用机制，以及免疫检查点抑制剂（immune checkpoint inhibitors，ICIs）在黑色素瘤中的应用。“肿瘤微生物组”、“质子泵抑制剂”与“预后”或为未来数年该领域的新研究热点。

**结论** 本研究筛选了全球范围内关于GM/CI相关性的文献，分析了其文献计量特征，识别出GM/CI领域的高被引论文，并深入解析了全球GM/CI研究的现状、热点与趋势，可为该领域研究者与从业者提供未来研究方向的参考。